NFL Anytime Touchdown Scorer Picks – Week 1 (9/7/25)

Week 1 is here, and the Anytime Touchdown Scorer market is hot—but savvy bettors know where the real value lies. Here's a ranked list of the Top 10 Most Likely TD Scorers entering the 9/7/25 games, featuring seasoned red-zone targets and explosive talent.

Anytime Touchdown Scorer Picks – Week 1

1. Ja'Marr Chase (WR, Cincinnati Bengals) (-135)

Chase remains Joe Burrow’s go-to weapon, especially in the red zone. Last season, Chase ranked #1 in red-zone targets (35) among wide receivers and scored 17 touchdowns. Facing a division rival in Week 1, expect Burrow to test Chase early and often, especially against a secondary that struggled to contain elite WR1s in 2024.

2. Derrick Henry (RB, Baltimore Ravens) (-160)

King Henry's reputation speaks for itself. Last season, he graded out as one of the NFL's most efficient red-zone rushers PFF. Paired with his ironman reputation and elite goal-line skill, he's a premier red-zone asset right out of the gate. He scored in both games against the Bills last season and had 199 rushing yards against them in the regular season.

3. Mike Evans (WR, Tampa Bay Bucs) (+110)

Evans continues to be one of the most consistent touchdown scorers in the NFL. He’s scored double-digit TDs in 4 of his last 5 seasons and thrives in contested catch situations. The Week 1 matchup is favorable—Evans faces a defense that allowed 22 TDs to wide receivers last season (worst in the NFL). With Baker Mayfield trusting him as a jump-ball specialist, Evans offers plus-money value. Evans scored 2 touchdowns against the Falcons last season.

4. Christian McCaffrey (RB, San Francisco 49ers) (-150)

CMC only played 4 games last season but led the league in total touchdowns in 2023 with 21. He is questionable this week but if he plays, he’s worth a play. He’s a dual-threat weapon both on the ground and through the air, making him nearly impossible to game plan against. Facing a defense that ranked 16th against the run last season, McCaffrey should see multiple red-zone opportunities. He’s one of the safest Anytime TD bets every week.

5. Jahmyr Gibbs (RB, Detroit Lions) (-115)

A fantasy darling and touchdown machine, Gibbs scored in each of his final 5 games with 10 total touchdowns during that stretch and led the league 16 rushing touchdowns. With the Lions embracing his receiving and rushing versatility, he’s on the list for Week 1 and will likely be hanging out on the list most weeks of the season.

6. James Conner (RB, Arizona Cardinals) (-155)

Conner quietly remained one of the league’s most efficient red-zone runners in 2024, punching in 9 touchdowns despite Arizona’s offensive struggles. Conner should continue to dominate short-yardage and goal-line carries. Against a defense that allowed 18 rushing TDs last season (tied for worst in the league), Conner has strong odds to score.

7. Malik Nabers (WR, New York Giants) (+150)

A deep sleeper with high-volume red-zone opportunities, Nabers offers upside for both receptions and big TD plays. Plus he has a QB that we think we can trust in Russell Wilson.

8. Kyren Williams (RB, Los Angeles Rams) (-140)

A goal-line bull in 2024, Williams led the league in carries inside the 5-yard line and was 5th in rushing TDs with 14. With his role secure heading into 2025, he's a solid Week 1 red-zone threat despite Houston's defense being solid against the run.

9. Jaylen Warren (RB, Pittsburgh Steelers) (+160)

With Najee Harris gone, Warren becomes the lead back and should be heavily involved in short-yardage and goal-line sets. Every player is plus money in this game but we like the value on Warren.

10. Stefon Diggs (WR, New England Patriots) (+175)

Now expected to be the WR1 in New England, Diggs brings his elite route-running and red-zone savvy to an offense desperate for reliable weapons. Despite a down year by his standards in 2024, Diggs finished with 3 touchdowns in 8 games. He’ll draw a Week 1 matchup against a secondary that ranked 16th against the pass. At almost 2 to 1 odds, Diggs is an excellent value for Anytime TD markets.

Anytime Touchdown Scorer Parlay Week 1

If you parlay all 10 of these guys to score in Week 1, the parlay pays 947 to 1 odds so $10 would pay $9,475.12.

Why These Picks Stand Out

• Red-Zone Volume: Chase, Henry, & Evans dominate red-zone touches.

• High Floor & Matchup Value: Williams, CMC, Conner shine early.

• Versatility & Scoring Range: Warren, Nabers, Diggs bring explosive upside.

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Final Thoughts

For Week 1 Anytime Touchdown Scorer picks, load up on prime red-zone targets and matchups. Chase, Henry, & Evans are must plays, with upside sleepers like Nabers and Warren rounding out your ticket.