49ers vs Rams Player Props: 3 Best Bets for TNF

49ers vs. Rams Player Props: 3 Best Bets for Thursday Night Football

Thursday Night Football takes us to Australia as the Los Angeles Rams and San Francisco 49ers meet at the Melbourne Cricket Ground in an NFC West matchup to open their 2026 seasons. The game kicks off Thursday, September 10 at 8:35 p.m. ET.

We're using the KofSports NFL Player Prop Trends research to find the best combination of recent performance, matchup history and playable numbers.

Three Rams stand out: Davante Adams, Kyren Williams and Matthew Stafford.

Here are our three favorite 49ers vs. Rams player props for Thursday night.

Davante Adams Over 52.5 Receiving Yards

Davante Adams has a history of producing against San Francisco, and we're getting a manageable number at 52.5 receiving yards.

Adams has cleared this number in seven of his last 10 games, but his recent performances against this exact opponent are what really catch our attention.

In his first matchup against San Francisco last season, Adams caught 5 passes on 11 targets for 88 yards. When the teams met again in November, he went for 6 catches and 77 yards, clearing Thursday's number by more than 20 yards in both games.

And this isn't just a two-game trend.

Adams has faced the 49ers seven times during his career and has produced 798 receiving yards — an average of 114.0 yards per game — with eight touchdowns. He's gone over 52.5 receiving yards in six of those seven career meetings.

San Francisco also finished last season allowing 232.4 passing yards per game, ranking 25th in the NFL.

Adams doesn't need another 88-yard performance to cash this one. We're asking for 53.

The Play: Davante Adams OVER 52.5 Receiving Yards

Kyren Williams Over 11.5 Receiving Yards

This might be our favorite trend-based prop on the board.

Kyren Williams has cleared 11.5 receiving yards in six consecutive games and seven of his last eight.

That's already enough to get our attention at such a low number. Then we look at what happened the last time Williams faced San Francisco.

On October 2, Williams was heavily involved in Matthew Stafford's passing attack, catching 8 of 10 targets for a career-high 66 receiving yards and two touchdowns.

Sixty-six.

We only need 12 on Thursday.

Williams finished last season with 36 receptions for 281 yards, averaging 16.5 receiving yards per game.

This isn't a bet that requires Williams to repeat anything close to his monster performance against San Francisco last October. One checkdown can get us halfway there, and two or three receptions could be enough to clear the entire number.

Given his recent receiving usage and what we've already seen him do against this defense, 11.5 is a number we're willing to attack.

The Play: Kyren Williams OVER 11.5 Receiving Yards

Matthew Stafford 2+ Passing Touchdowns (-162)

We're willing to eat a little more juice on the final prop because Matthew Stafford's touchdown production has been outstanding.

Stafford threw 46 touchdown passes in 17 regular-season games last year, averaging 2.7 per game. He threw at least one touchdown in every game and recorded multiple passing touchdowns in 15 of 17 games.

Then there's what he did against San Francisco.

Stafford absolutely shredded the 49ers in their two meetings last season:

October 2: 389 yards, 3 TD, 0 INT
November 9: 280 yards, 4 TD, 0 INT

Combined: 669 passing yards, 7 touchdowns and zero interceptions.

That's an average of 3.5 touchdown passes per game against the 49ers.

We're only asking for two.

San Francisco also allowed 1.7 passing touchdowns per game last season, and Stafford enters 2026 surrounded by an offense that led the NFL with 394.6 total yards per game a year ago.

At -162, this is more expensive than the traditional -110 prop we'd usually target, but Stafford's consistency makes it worthy of inclusion.

The Play: Matthew Stafford 2+ Passing Touchdowns (-162)

Best 49ers vs. Rams Player Props

Our three favorite player props for Thursday Night Football are:

• Davante Adams OVER 52.5 Receiving Yards
• Kyren Williams OVER 11.5 Receiving Yards
• Matthew Stafford 2+ Passing Touchdowns (-162)

There's also some correlation between what we're betting.

We're expecting Los Angeles to have success through the air. Stafford throwing multiple touchdowns fits that script, while Adams gives us exposure farther downfield and Williams gives us an outlet underneath.

But each prop has enough supporting data to stand on its own.

Adams has cleared his receiving number in both Rams-49ers meetings and six of seven career games against San Francisco. Williams enters on a six-game streak over his receiving number and exploded for 66 receiving yards in his previous matchup with the 49ers. Stafford threw seven touchdowns against San Francisco in two games last year.

That's enough for all three to make our Thursday night card.

How We Research NFL Player Props

The goal isn't simply finding a player who has gone over a number recently.

We're looking for situations where recent hit rates, player usage, matchup history and the current betting line point in the same direction.

That's why KofSports tracks NFL player prop results across recent games and allows bettors to quickly compare Last 5, Last 10, season and opponent history.

A trend alone doesn't make a bet. But when multiple signals line up — as they do with several Rams props Thursday night — we pay attention.